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15 September 2021 - Late treatment study
Emergence of SARS-CoV-2 Resistance with Monoclonal Antibody Therapy
Choudhary et al., medRxiv, doi:10.1101/2021.09.03.21263105 (Preprint)
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Analysis of ACTIV-2/A5401, showing the potential for rapid emergence of resistance during monoclonal antibody treatment, resulting in prolonged high level viral loads and clinical worsening. Treatment-emergent resistance mutations were more common after bamlanivimab 700mg (7% of 111 vs 0% of 112 participants, p=0.003). NCT04518410.
Choudhary et al., 9/15/2021, preprint, 28 authors.
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