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00.250.50.7511.251.51.752+Chen (RCT)0.26[0.09-0.75]hosp.5/3099/143RRCITreatmentControlGottlieb (RCT)0.29[0.09-0.96]hosp./ER4/1017/52Lilly (DB RCT)0.08[0.00-1.43]death0/5114/258Tau​2 = 0.00; I​2 = 0.0%Early treatment0.25[0.12-0.54]9/92120/45375% improvementACTIV-3/T.. (RCT)2.00[0.69-5.83]death9/1635/151RRCITreatmentControlBariola0.33[0.10-1.01]death4/23412/234Tau​2 = 1.30; I​2 = 80.7%Late treatment0.82[0.14-4.77]13/39717/38518% improvementLilly (RCT)0.43[0.27-0.69]symp. case483482RRCITreatmentControlTau​2 = 0.00; I​2 = 0.0%PrEP0.43[0.27-0.69]0/4830/48257% improvementAll studies0.43[0.23-0.81]22/1,80137/1,32057% improvement6 bamlanivimab COVID-19 studiesc19ly.com 5/16/21Tau​2 = 0.30; I​2 = 53.3%; Z = 2.61 (p = 0.0045)Lower RiskIncreased Risk
LY-CoV555 and LY-CoV016 are two SARS-CoV-2 neutralizing antibodies which bind complementary regions of the SARS-CoV-2 spike protein. Studies are investigating their use in monotherapy and in combination. Submit updates/corrections below.
3/30
Late Bariola et al., medRxiv, doi:10.1101/2021.03.25.21254322 (Preprint) death, ↓66.8%, p=0.05 Impact of monoclonal antibody treatment on hospitalization and mortality among non-hospitalized adults with SARS-CoV-2 infection
Retrospective 234 patients receiving bamlanivimab and 234 matched controls, showing lower hospitalization and mortality with treatment. Greater benefit was seen with administration within 4 days of their positive COVID-19 test.
3/10
Early Lilly, Press Release (Preprint) death, ↓92.3%, p=0.01 Lilly's bamlanivimab and etesevimab together reduced hospitalizations and death in Phase 3 trial for early COVID-19
Results from the BLAZE-1 study of combined bamlanivimab/etesevimab, showing significantly lower mortality and combined mortality/hospitalization with treatment.
1/21
PrEP Lilly, Press Release (Preprint) symp. case, ↓57.0%, p=0.0002 Lilly's neutralizing antibody bamlanivimab (LY-CoV555) prevented COVID-19 at nursing homes in the BLAZE-2 trial, reducing risk by up to 80 percent for residents
Press release on the BLAZE-2 trial at nursing homes showing significantly lower symptomatic COVID-19 with treatment.
1/21
Early Gottlieb et al., JAMA, doi:10.1001/jama.2021.0202 (Peer Reviewed) hosp./ER, ↓70.6%, p=0.05 Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19
RCT for LY-CoV555 monotherapy and LY-CoV555/LY-CoV016 combination therapy with 592 patients showing lower hospitalization/ER visits with treatment. For viral load at day 11, a statistically significant reduction was found with combinatio..
12/22
Late ACTIV-3/TICO LY-CoV555 study group, NEJM, doi:0.1056/NEJMoa2033130 (Peer Reviewed) death, ↑100%, p=0.22 A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19
Late stage RCT of LY-CoV555 added to remdesivir, showing non-statistically significant higher mortality with the addition of LY-CoV555.
10/28
Early Chen et al., NEJM, doi:10.1056/NEJMoa2029849 (Peer Reviewed) hosp., ↓74.3%, p=0.02 SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19
Interim analysis of the BLAZE-1 phase 2 trial of outpatients showing lower hospitalization or ER visits (1.6% versus 6.3%), and improvements in symptoms and viral load compared to placebo. NCT04427501
10/26
News Lilly, Press Release (News) news Lilly Statement Regarding NIH’s ACTIV-3 Clinical Trial
ACTIV-3 intermin analysis shows LY-CoV555 is unlikely to help hospitalized patients. ACTIV-2, BLAZE-1 and BLAZE-2 trials remain ongoing.
10/7
Early Lilly, Press Release (Preprint) hosp., ↓84.5%, p=0.05 SARS-CoV-2 neutralizing antibody program update
Interim results from the BLAZE-1 outpatient RCT showing improvements in viral load, symptoms and hospitalization. Combination therapy significantly reduced viral load at day 11 (p=0.011). A greater effect is seen at day 7 (p<0.001). The ..
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