Ganesh, 3,621 patient bamlanivimab/etesevimab late treatment study: 74% lower mortality [p=0.11], 49% lower ICU admission [p=0.1], and 37% lower hospitalization [p=0.01] https://c19p.org/ganesh
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Intravenous bamlanivimab use associates with reduced hospitalization in high-risk patients with mild to moderate COVID-19
et al., Journal of Clinical Investigation, doi:10.1172/JCI151697
Retrospective 2,335 bamlanivimab patients and 2,335 PSM controls in the USA, showing significantly lower hospitalization with treatment.Efficacy is highly variant dependent. Unlikely to be effective for omicron [Liu, Sheward, VanBlargan].
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Liu et al., bioRxiv, doi:10.1101/2021.12.14.472719,
Striking Antibody Evasion Manifested by the Omicron Variant of SARS-CoV-2,
https://www.biorxiv.org/content/10.1101/2021.12.14.472719.
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risk of death, 74.4% lower, RR 0.26, p = 0.11, treatment 2 of 1,789 (0.1%), control 8 of 1,832 (0.4%), NNT 308, day 28.
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risk of ICU admission, 48.8% lower, RR 0.51, p = 0.10, treatment 10 of 1,789 (0.6%), control 20 of 1,832 (1.1%), NNT 188, day 28.
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risk of hospitalization, 37.4% lower, RR 0.63, p = 0.01, treatment 44 of 1,789 (2.5%), control 72 of 1,832 (3.9%), NNT 68, day 28, primary outcome.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Ganesh et al., 10/1/2021, retrospective, USA, North America, peer-reviewed, median age 63.0, 20 authors.
Late treatment
is less effective
is less effective
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