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Home   COVID-19 treatment studies for Bamlanivimab/etesevimab  COVID-19 treatment studies for Bamlaniv../e..  C19 studies: Bamlaniv../e..  Bamlaniv../e..   Select treatmentSelect treatmentTreatmentsTreatments
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0 0.5 1 1.5 2+ Mortality 80% Improvement Relative Risk Hospitalization 53% Hospitalization/ER 27% primary c19ly.com Webb et al. Bamlaniv../e.. for COVID-19 EARLY Favors bamlanivimab/e.. Favors control
Webb, 6,015 patient bamlanivimab/etesevimab early treatment study: 80% lower mortality [p=0.09], 53% lower hospitalization [p<0.0001], and 27% fewer combined hospitalization/ER visits [p<0.0001] https://c19p.org/webb
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Real-World Effectiveness and Tolerability of Monoclonal Antibody Therapy for Ambulatory Patients with Early COVID-19
Webb et al., Open Forum Infectious Diseases, doi:10.1093/ofid/ofab331
23 Jun 2021    Source   PDF   Share   Tweet
Retrospective 479 patients treated with bamlanivimab showing lower mortality, hospital admission, and emergency department visits with treatment. Authors incorrectly state that "no other COVID-19 therapies for ambulatory patients have proven effective".
Efficacy is highly variant dependent. Unlikely to be effective for omicron [Liu, Sheward, VanBlargan].
risk of death, 79.7% lower, RR 0.20, p = 0.09, treatment 1 of 479 (0.2%), control 57 of 5,536 (1.0%), NNT 122.
risk of hospitalization, 52.7% lower, RR 0.47, p < 0.001, treatment 22 of 479 (4.6%), control 538 of 5,536 (9.7%), NNT 20.
risk of hospitalization/ER, 26.8% lower, RR 0.73, p < 0.001, treatment 65 of 479 (13.6%), control 1,018 of 5,536 (18.4%), NNT 21, odds ratio converted to relative risk, primary outcome.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Webb et al., 6/23/2021, retrospective, USA, North America, peer-reviewed, 14 authors.
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