Webb, 6,015 patient bamlanivimab/etesevimab early treatment study: 80% lower mortality [p=0.09], 53% lower hospitalization [p<0.0001], and 27% fewer combined hospitalization/ER visits [p<0.0001] https://c19p.org/webb
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Real-World Effectiveness and Tolerability of Monoclonal Antibody Therapy for Ambulatory Patients with Early COVID-19
et al., Open Forum Infectious Diseases, doi:10.1093/ofid/ofab331
Retrospective 479 patients treated with bamlanivimab showing lower mortality, hospital admission, and emergency department visits with treatment. Authors incorrectly state that "no other COVID-19 therapies for ambulatory patients have proven effective".Efficacy is highly variant dependent. Unlikely to be effective for omicron [Liu, Sheward, VanBlargan].
1.
Liu et al., bioRxiv, doi:10.1101/2021.12.14.472719,
Striking Antibody Evasion Manifested by the Omicron Variant of SARS-CoV-2,
https://www.biorxiv.org/content/10.1101/2021.12.14.472719.
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risk of death, 79.7% lower, RR 0.20, p = 0.09, treatment 1 of 479 (0.2%), control 57 of 5,536 (1.0%), NNT 122.
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risk of hospitalization, 52.7% lower, RR 0.47, p < 0.001, treatment 22 of 479 (4.6%), control 538 of 5,536 (9.7%), NNT 20.
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risk of hospitalization/ER, 26.8% lower, RR 0.73, p < 0.001, treatment 65 of 479 (13.6%), control 1,018 of 5,536 (18.4%), NNT 21, odds ratio converted to relative risk, primary outcome.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Webb et al., 6/23/2021, retrospective, USA, North America, peer-reviewed, 14 authors.
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