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Bamlanivimab study #2   Meta Analysis
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Hospitalization 74% Imp. Relative Risk, 95% CI Chen: SARS-CoV-2 Neutralizing Antibody LY-CoV555 in .. c19ly.com/chen2.html Favors bamlanivimab Favors control
10/28 Early treatment study
Chen et al., NEJM, doi:10.1056/NEJMoa2029849 (Peer Reviewed)
SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19
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Interim analysis of the BLAZE-1 phase 2 trial of outpatients showing lower hospitalization or ER visits (1.6% versus 6.3%), and improvements in symptoms and viral load compared to placebo.
NCT04427501
risk of hospitalization, 74.3% lower, RR 0.26, p = 0.02, treatment 5 of 309 (1.6%), control 9 of 143 (6.3%).
Chen et al., 10/28/2020, Randomized Controlled Trial, USA, North America, peer-reviewed, 12 authors.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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