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Home   COVID-19 treatment studies for Bamlanivimab/etesevimab  COVID-19 treatment studies for Bamlaniv../e..  C19 studies: Bamlaniv../e..  Bamlaniv../e..   Select treatmentSelect treatmentTreatmentsTreatments
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0 0.5 1 1.5 2+ Hospitalization 74% Improvement Relative Risk c19ly.com Chen et al. NCT04427501 Bamlaniv../e.. RCT EARLY TREATMENT Favors bamlanivimab/e.. Favors control
Chen, 452 patient bamlanivimab/etesevimab early treatment RCT: 74% lower hospitalization [p=0.02] https://c19p.org/chen2
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SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19
Chen et al., NEJM, doi:10.1056/NEJMoa2029849
28 Oct 2020    Source   PDF   Share   Tweet
Interim analysis of the BLAZE-1 phase 2 trial of outpatients showing lower hospitalization or ER visits (1.6% versus 6.3%), and improvements in symptoms and viral load compared to placebo. NCT04427501.
Efficacy is highly variant dependent. Unlikely to be effective for omicron [Liu, Sheward, VanBlargan].
risk of hospitalization, 74.3% lower, RR 0.26, p = 0.02, treatment 5 of 309 (1.6%), control 9 of 143 (6.3%), NNT 21.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Chen et al., 10/28/2020, Randomized Controlled Trial, USA, North America, peer-reviewed, 12 authors, average treatment delay 4.0 days, trial NCT04427501.
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