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00.250.50.7511.251.51.752+Chen (RCT)74%0.26 [0.09-0.75]hosp.5/3099/143Improvement, RR [CI]TreatmentControlGottlieb (RCT)71%0.29 [0.09-0.96]hosp./ER4/1017/52Lilly (DB RCT)92%0.08 [0.00-1.43]death0/5114/258Tau​2 = 0.00; I​2 = 0.0%Early treatment75%0.25 [0.12-0.54]9/92120/45375% improvementACTIV-3/T.. (RCT)-100%2.00 [0.69-5.83]death9/1635/151Improvement, RR [CI]TreatmentControlBariola67%0.33 [0.10-1.01]death4/23412/234Tau​2 = 1.30; I​2 = 80.7%Late treatment18%0.82 [0.14-4.77]13/39717/38518% improvementLilly (RCT)57%0.43 [0.27-0.69]symp. case483482Improvement, RR [CI]TreatmentControlTau​2 = 0.00; I​2 = 0.0%PrEP57%0.43 [0.27-0.69]0/4830/48257% improvementAll studies57%0.43 [0.23-0.81]22/1,80137/1,32057% improvement6 bamlanivimab COVID-19 studiesc19ly.com 6/25/21Tau​2 = 0.30; I​2 = 53.3%; Z = 2.61 (p = 0.0045)Lower RiskIncreased Risk 00.250.50.7511.251.51.752+Lilly (DB RCT)92%0.08 [0.00-1.43]0/5114/258Improvement, RR [CI]TreatmentControlTau​2 = 0.00; I​2 = 0.0%Early treatment92%0.08 [0.00-1.43]0/5114/25892% improvementACTIV-3/T.. (RCT)-100%2.00 [0.69-5.83]9/1635/151Improvement, RR [CI]TreatmentControlBariola67%0.33 [0.10-1.01]4/23412/234Tau​2 = 1.30; I​2 = 80.7%Late treatment18%0.82 [0.14-4.77]13/39717/38518% improvementAll studies48%0.52 [0.10-2.71]13/90821/64348% improvement3 bamlanivimab COVID-19 mortality resultsc19ly.com 6/25/21Tau​2 = 1.46; I​2 = 73.7%; Z = 0.78 (p = 0.22)Lower RiskIncreased Risk 00.250.50.7511.251.51.752+Chen (RCT)74%0.26 [0.09-0.75]hosp.5/3099/143Improvement, RR [CI]TreatmentControlTau​2 = 0.00; I​2 = 0.0%Early treatment74%0.26 [0.09-0.75]5/3099/14374% improvementBariola61%0.39 [0.22-0.70]hosp.15/23439/234Improvement, RR [CI]TreatmentControlTau​2 = 0.00; I​2 = 0.0%Late treatment61%0.39 [0.22-0.70]15/23439/23461% improvementAll studies64%0.36 [0.22-0.59]20/54348/37764% improvement2 bamlanivimab COVID-19 hospitalization resultsc19ly.com 6/25/21Tau​2 = 0.00; I​2 = 0.0%; Z = 4.01 (p < 0.0001)Lower RiskIncreased Risk 00.250.50.7511.251.51.752+Chen (RCT)74%0.26 [0.09-0.75]hosp.5/3099/143Improvement, RR [CI]TreatmentControlGottlieb (RCT)71%0.29 [0.09-0.96]hosp./ER4/1017/52Lilly (DB RCT)92%0.08 [0.00-1.43]death0/5114/258Tau​2 = 0.00; I​2 = 0.0%Early treatment75%0.25 [0.12-0.54]9/92120/45375% improvementACTIV-3/T.. (RCT)-100%2.00 [0.69-5.83]death9/1635/151Improvement, RR [CI]TreatmentControlBariola67%0.33 [0.10-1.01]death4/23412/234Tau​2 = 1.30; I​2 = 80.7%Late treatment18%0.82 [0.14-4.77]13/39717/38518% improvementAll studies59%0.41 [0.16-1.06]22/1,31837/83859% improvement5 bamlanivimab COVID-19 serious outcomesc19ly.com 6/25/21Tau​2 = 0.67; I​2 = 62.5%; Z = 1.84 (p = 0.033)Lower RiskIncreased Risk 00.250.50.7511.251.51.752+Chen (RCT)74%0.26 [0.09-0.75]hosp.5/3099/143Improvement, RR [CI]TreatmentControlGottlieb (RCT)71%0.29 [0.09-0.96]hosp./ER4/1017/52Gottlieb (RCT)80%0.20 [0.03-1.56]hosp./ER1/377/52Gottlieb (RCT)75%0.25 [0.03-1.92]hosp./ER1/307/52Gottlieb (RCT)56%0.44 [0.10-1.98]hosp./ER2/347/52Gottlieb (RCT)92%0.08 [0.00-1.39]hosp./ER0/317/52Lilly (DB RCT)92%0.08 [0.00-1.43]death0/5114/258Lilly (DB RCT)87%0.13 [0.05-0.40]hosp./death4/51115/258ACTIV-3/T.. (RCT)-100%2.00 [0.69-5.83]death9/1635/151Bariola67%0.33 [0.10-1.01]death4/23412/234Bariola61%0.39 [0.22-0.70]hosp.15/23439/234Lilly (RCT)57%0.43 [0.27-0.69]symp. case483482Lilly (RCT)80%0.20 [0.08-0.50]symp. case150149bamlanivimab COVID-19 outcomesc19ly.com 6/25/21Lower RiskIncreased Risk
Please send us corrections, updates, or comments. Vaccines and treatments are both extremely valuable and complementary. All practical, effective, and safe means should be used. Elimination of COVID-19 is a race against viral evolution. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. Denying the efficacy of any method increases the risk of COVID-19 becoming endemic; and increases mortality, morbidity, and collateral damage. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. Treatment protocols for physicians are available from the FLCCC.
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