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5/18 N/A
Focosi et al., Research Square, doi:10.21203/rs.3.rs-524959/v1 (Preprint)
Emergence of SARS-CoV-2 Spike Escape Mutation Q493r After Bamlanivimab/Etesevimab Treatment for COVID-19
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Case study showing that a mutation resistant to both bamlanivimab and etesevimab can arise in vivo. Authors note that accelerated evolution can occur under selective pressure from therapeutic interventions with neutralizing antibodies, and that bamlanivimab was withdrawn as a monotherapy because of failure against E484K-positive SARS-CoV-2 variants.
Focosi et al., 5/18/2021, preprint, 7 authors.
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