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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality 95% Improvement Relative Risk Death/hospitalization 70% primary Recovery time 11% Viral clearance 67% c19ly.com Dougan et al. NCT04427501 Bamlaniv../e.. RCT EARLY Favors bamlanivimab/e.. Favors control
Dougan, 1,035 patient bamlanivimab/etesevimab early treatment RCT: 95% lower mortality [p=0.002], 70% lower combined mortality/hospitalization [p=0.0002], 11% faster recovery [p=0.007], and 67% improved viral clearance [p<0.0001] https://c19p.org/dougan
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Bamlanivimab plus Etesevimab in Mild or Moderate Covid-19
Dougan et al., New England Journal of Medicine, doi:10.1056/NEJMoa2102685
7 Oct 2021    Source   PDF   Share   Tweet
Results from the BLAZE-1 RCT of combined bamlanivimab/etesevimab, showing significantly lower mortality and combined mortality/hospitalization with treatment. NCT04427501.
Efficacy is highly variant dependent. Unlikely to be effective for omicron [Liu, Sheward, VanBlargan].
risk of death, 94.7% lower, RR 0.05, p = 0.002, treatment 0 of 518 (0.0%), control 9 of 517 (1.7%), NNT 57, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), COVID-19 deaths.
risk of death/hospitalization, 69.5% lower, RR 0.30, p < 0.001, treatment 11 of 518 (2.1%), control 36 of 517 (7.0%), NNT 21, primary outcome.
recovery time, 11.1% lower, relative time 0.89, p = 0.007, treatment 518, control 517, sustained resolution of symptoms.
risk of no viral clearance, 66.6% lower, RR 0.33, p < 0.001, treatment 50 of 508 (9.8%), control 147 of 499 (29.5%), NNT 5.1, day 7, persistently high viral load.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Dougan et al., 10/7/2021, Double Blind Randomized Controlled Trial, USA, North America, peer-reviewed, 33 authors, average treatment delay 4.0 days, trial NCT04427501.
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