Dale, 75 patient bamlanivimab/etesevimab early treatment study: 89% lower mortality [p=0.01] and 86% lower progression [p=0.002] https://c19p.org/dale
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Clinical Outcomes of Monoclonal Antibody Therapy During a COVID ‐19 Outbreak in a Skilled Nursing Facility‐Arizona, 2021
et al., Journal of the American Geriatrics Society, doi:10.1111/jgs.17705
Retrospective 75 COVID+ patients in a skilled nursing facility in the USA, 56 treated within a median of 2 days from symptom onset with bamlanivimab, showing significantly lower mortality with treatment.Efficacy is highly variant dependent. Unlikely to be effective for omicron [Liu, Sheward, VanBlargan].
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Liu et al., bioRxiv, doi:10.1101/2021.12.14.472719,
Striking Antibody Evasion Manifested by the Omicron Variant of SARS-CoV-2,
https://www.biorxiv.org/content/10.1101/2021.12.14.472719.
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risk of death, 89.2% lower, RR 0.11, p = 0.010, treatment 5 of 56 (8.9%), control 9 of 19 (47.4%), NNT 2.6, adjusted per study, odds ratio converted to relative risk, multivariable.
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risk of progression, 86.3% lower, RR 0.14, p = 0.002, treatment 6 of 56 (10.7%), control 10 of 19 (52.6%), NNT 2.4, adjusted per study, odds ratio converted to relative risk, oxygen therapy, multivariable.
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risk of progression, 53.8% lower, RR 0.46, p = 0.35, treatment 6 of 56 (10.7%), control 3 of 19 (15.8%), adjusted per study, odds ratio converted to relative risk, ER visit or hospitalization, multivariable.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Dale et al., 2/9/2022, retrospective, USA, North America, peer-reviewed, 14 authors, average treatment delay 2.0 days.
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