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Home   COVID-19 treatment studies for Bamlanivimab/etesevimab  COVID-19 treatment studies for Bamlaniv../e..  C19 studies: Bamlaniv../e..  Bamlaniv../e..   Select treatmentSelect treatmentTreatmentsTreatments
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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Hospitalization 25% Improvement Relative Risk Hospitalization (b) 52% Hospitalization (c) -1% Time to symptom improvement -14% primary Time to symptom improv.. (b) -17% primary Viral load 26% Viral load (b) 35% c19ly.com Chew et al. NCT04518410 Bamlaniv../e.. RCT LATE TREATMENT Favors bamlanivimab/e.. Favors control
Chew, 317 patient bamlanivimab/etesevimab late treatment RCT: 25% lower hospitalization [p=0.6], 14% slower recovery [p=0.97], and 26% improved viral clearance [p=0.002] https://c19p.org/chew
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Bamlanivimab reduces nasopharyngeal SARS-CoV-2 RNA levels but not symptom duration in non-hospitalized adults with COVID-19
Chew et al., medRxiv, doi:10.1101/2021.12.17.21268009 (Preprint)
21 Dec 2021    Source   PDF   Share   Tweet
RCT 317 outpatients in the USA showing faster viral load and inflammatory biomarker decline, but no significant differences in clinical outcomes. ACTIV-2/A5401. NCT04518410. Supplementary data is not currently available.
Efficacy is highly variant dependent. Unlikely to be effective for omicron [Liu, Sheward, VanBlargan].
risk of hospitalization, 25.5% lower, RR 0.75, p = 0.60, treatment 6 of 159 (3.8%), control 8 of 158 (5.1%), NNT 78, combined.
risk of hospitalization, 52.1% lower, RR 0.48, p = 0.43, treatment 2 of 48 (4.2%), control 4 of 46 (8.7%), NNT 22, 7000mg, day 28.
risk of hospitalization, 0.9% higher, RR 1.01, p = 1.00, treatment 4 of 111 (3.6%), control 4 of 112 (3.6%), 700mg, day 28.
relative time to symptom improvement, 13.5% higher, relative time 1.14, p = 0.97, treatment 48, control 46, 7000mg, primary outcome.
relative time to symptom improvement, 17.1% higher, relative time 1.17, p = 0.08, treatment 111, control 112, 700mg, primary outcome.
viral load, 25.6% lower, relative load 0.74, p = 0.002, treatment 48, control 46, 7000mg, day 3.
viral load, 35.3% lower, relative load 0.65, p = 0.07, treatment 111, control 112, 700mg, day 3.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Chew et al., 12/21/2021, Randomized Controlled Trial, USA, North America, preprint, 23 authors, study period 19 August, 2020 - 17 November, 2020, average treatment delay 6.0 days, trial NCT04518410.
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Late treatment
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